Dr. Wenzhi Tian | FRP in Health & Medicine | Best Researcher Award

Doctorate at ImmuneOnco Biopharmaceuticals Shanghai Inc, China

Profile:

Current Position 👨‍💼

Dr. Tian Wenzhi serves as the Chairman of the Board, Chief Executive Officer, Chief Scientific Officer, and Executive Director of his Group. Since founding the company in June 2015, he has led its strategic planning, business management, and research and development efforts. Under his leadership, the Group has emerged as a driving force in biomedical innovation, spearheading projects from discovery to clinical studies. Dr. Tian also oversees subsidiaries like ImmuneTANK, ImmuneOnco Shanghai, Macroimmune, ImmuneOnco Hong Kong, and ImmuneCare.

Publication Achievements 🔖

Dr. Tian’s research contributions have been significant in the biomedical domain, with his work focusing on monoclonal antibody drugs and novel tumor targets. His scientific publications include advancements in B cell functions and breakthroughs in tumor immunology, many of which are widely cited and recognized in international journals. His ability to translate complex research into actionable therapies underscores his contribution to the scientific community.

Ongoing Research 🧬

Dr. Tian’s ongoing research is concentrated on antitumor antibody drugs, autoimmune diseases, and cancer immunotherapy. His innovative approaches involve leveraging cutting-edge bioinformatics tools to identify and validate new drug targets. This ensures precision and effectiveness in therapeutic development, particularly in addressing unmet needs in oncology and immunology.

Research Interests 🌐

Dr. Tian’s research interests encompass a wide array of fields, Cancer Immunotherapy-Developing monoclonal antibodies to target specific tumor pathways. Bioinformatics-Using computational techniques to analyze biological data for drug discovery. Autoimmune Diseases-Investigating the molecular basis and potential therapeutic interventions. CMC Development-Overseeing Chemistry, Manufacturing, and Controls to ensure drug safety and efficacy.

Academic Background 🎓

Dr. Tian’s academic journey began at the Medical School of Zhengzhou University, where he served as a teaching assistant from 1990 to 1993. He later pursued advanced research at Weill Cornell Medical College, focusing on c-Rel regulated genes in B cell functions. This foundational work laid the groundwork for his illustrious career in biomedical research.

Scholarships and Awards 🏆

Dr. Tian’s dedication has earned him prestigious recognitions, Senior Biomedical Engineer Certification by Shanghai Municipal Human Resources and Social Security Bureau (2019). Visiting and distinguished professorships at Zhengzhou University, Henan Medical University, and Fudan University, highlighting his academic and industry leadership.

Bioinformatics Expertise 🔄

Dr. Tian integrates bioinformatics into his research to streamline drug discovery processes. By employing computational tools, he enhances the precision of target selection and validation, contributing to the development of science-driven solutions for complex diseases.

Professional Associations 📚

Dr. Tian actively participates in several biomedical and scientific societies, fostering collaboration and staying at the forefront of emerging trends. His memberships underscore his commitment to advancing global healthcare through research.

Training & Workshops 🏢

Throughout his career, Dr. Tian has organized and participated in numerous international workshops and training sessions, focusing on monoclonal antibody development, clinical studies, and advanced manufacturing techniques. These initiatives have enriched his expertise and disseminated knowledge across the industry.

Oral Presentations📈

Dr. Tian has delivered impactful presentations at prestigious conferences worldwide, Innovative approaches to antibody drug development. The role of c-Rel genes in immune regulation. Strategies for effective clinical trial management.

Tasks Completed as a Researcher 🔄

Dr. Tian’s career is marked by significant achievements, Establishing a robust pipeline for antitumor drug discovery. Cloning and studying critical genes involved in B cell function. Leading CMC development and ensuring regulatory compliance. Overseeing multiple clinical studies that advance therapeutic applications.

Success Factors 🌟

Dr. Tian attributes his success to a combination of visionary leadership, a science-driven approach, and collaborative partnerships. His ability to bridge the gap between academic research and clinical application has been instrumental in his Group’s success.

Laboratory Experience 🔧

Dr. Tian’s extensive laboratory experience spans over three decades. From cloning genes at Weill Cornell Medical College to leading monoclonal antibody research at ImClone Systems, his hands-on expertise has shaped cutting-edge therapies. His publications, often resulting from meticulous lab work, are testaments to his enduring contribution to biomedical science.

Conclusion 🖖

Dr. Tian Wenzhi’s illustrious career is a testament to his unwavering commitment to biomedical innovation. From pioneering research to fostering global collaborations, his work continues to make a profound impact on healthcare and science. Through his leadership, vision, and dedication, Dr. Tian exemplifies the transformative power of scientific discovery.

📖Publications:

Paper Title: Development of bioassay platforms for biopharmaceuticals using Jurkat-CAR cells by AICD

  • Authors: Chen, D.; Li, S.; Yang, Y.; Zhang, R.; Tian, W.
  • Journal: Journal of Pharmaceutical and Biomedical Analysis
  • Year: 2024

Paper Title: IMM2520, a novel anti-CD47/PD-L1 bispecific antibody for cancer immune therapy

  • Authors: Yang, C.; Li, S.; Chen, D.; Tu, X.; Tian, W.
  • Journal: Heliyon
  • Year: 2024

Paper Title: Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy

  • Authors: Zhang, B.; Shi, J.; Shi, X.; Xu, L.; Li, W.
  • Journal: Drug Resistance Updates
  • Year: 2024

Paper Title: Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions

  • Authors: Li, X.; Tian, W.; Jiang, Z.; Leng, X.; Yu, J.
  • Journal: Cancer Immunology, Immunotherapy
  • Year: 2024

Paper Title: DNp73 enhances tumor progression and immune evasion in multiple myeloma by targeting the MYC and MYCN pathways

  • Authors: Liu, L.; Gong, D.; Sun, H.; An, G.; Hao, M.
  • Journal: Frontiers in Immunology
  • Year: 2024

 

Wenzhi Tian | FRP in Health & Medicine | Best Researcher Award

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