Wenzhi Tian | FRP in Health & Medicine | Best Researcher Award

Dr. Wenzhi Tian | FRP in Health & Medicine | Best Researcher Award

Doctorate at ImmuneOnco Biopharmaceuticals Shanghai Inc, China

Profile:

Current Position 👨‍💼

Dr. Tian Wenzhi serves as the Chairman of the Board, Chief Executive Officer, Chief Scientific Officer, and Executive Director of his Group. Since founding the company in June 2015, he has led its strategic planning, business management, and research and development efforts. Under his leadership, the Group has emerged as a driving force in biomedical innovation, spearheading projects from discovery to clinical studies. Dr. Tian also oversees subsidiaries like ImmuneTANK, ImmuneOnco Shanghai, Macroimmune, ImmuneOnco Hong Kong, and ImmuneCare.

Publication Achievements 🔖

Dr. Tian’s research contributions have been significant in the biomedical domain, with his work focusing on monoclonal antibody drugs and novel tumor targets. His scientific publications include advancements in B cell functions and breakthroughs in tumor immunology, many of which are widely cited and recognized in international journals. His ability to translate complex research into actionable therapies underscores his contribution to the scientific community.

Ongoing Research 🧬

Dr. Tian’s ongoing research is concentrated on antitumor antibody drugs, autoimmune diseases, and cancer immunotherapy. His innovative approaches involve leveraging cutting-edge bioinformatics tools to identify and validate new drug targets. This ensures precision and effectiveness in therapeutic development, particularly in addressing unmet needs in oncology and immunology.

Research Interests 🌐

Dr. Tian’s research interests encompass a wide array of fields, Cancer Immunotherapy-Developing monoclonal antibodies to target specific tumor pathways. Bioinformatics-Using computational techniques to analyze biological data for drug discovery. Autoimmune Diseases-Investigating the molecular basis and potential therapeutic interventions. CMC Development-Overseeing Chemistry, Manufacturing, and Controls to ensure drug safety and efficacy.

Academic Background 🎓

Dr. Tian’s academic journey began at the Medical School of Zhengzhou University, where he served as a teaching assistant from 1990 to 1993. He later pursued advanced research at Weill Cornell Medical College, focusing on c-Rel regulated genes in B cell functions. This foundational work laid the groundwork for his illustrious career in biomedical research.

Scholarships and Awards 🏆

Dr. Tian’s dedication has earned him prestigious recognitions, Senior Biomedical Engineer Certification by Shanghai Municipal Human Resources and Social Security Bureau (2019). Visiting and distinguished professorships at Zhengzhou University, Henan Medical University, and Fudan University, highlighting his academic and industry leadership.

Bioinformatics Expertise 🔄

Dr. Tian integrates bioinformatics into his research to streamline drug discovery processes. By employing computational tools, he enhances the precision of target selection and validation, contributing to the development of science-driven solutions for complex diseases.

Professional Associations 📚

Dr. Tian actively participates in several biomedical and scientific societies, fostering collaboration and staying at the forefront of emerging trends. His memberships underscore his commitment to advancing global healthcare through research.

Training & Workshops 🏢

Throughout his career, Dr. Tian has organized and participated in numerous international workshops and training sessions, focusing on monoclonal antibody development, clinical studies, and advanced manufacturing techniques. These initiatives have enriched his expertise and disseminated knowledge across the industry.

Oral Presentations📈

Dr. Tian has delivered impactful presentations at prestigious conferences worldwide, Innovative approaches to antibody drug development. The role of c-Rel genes in immune regulation. Strategies for effective clinical trial management.

Tasks Completed as a Researcher 🔄

Dr. Tian’s career is marked by significant achievements, Establishing a robust pipeline for antitumor drug discovery. Cloning and studying critical genes involved in B cell function. Leading CMC development and ensuring regulatory compliance. Overseeing multiple clinical studies that advance therapeutic applications.

Success Factors 🌟

Dr. Tian attributes his success to a combination of visionary leadership, a science-driven approach, and collaborative partnerships. His ability to bridge the gap between academic research and clinical application has been instrumental in his Group’s success.

Laboratory Experience 🔧

Dr. Tian’s extensive laboratory experience spans over three decades. From cloning genes at Weill Cornell Medical College to leading monoclonal antibody research at ImClone Systems, his hands-on expertise has shaped cutting-edge therapies. His publications, often resulting from meticulous lab work, are testaments to his enduring contribution to biomedical science.

Conclusion 🖖

Dr. Tian Wenzhi’s illustrious career is a testament to his unwavering commitment to biomedical innovation. From pioneering research to fostering global collaborations, his work continues to make a profound impact on healthcare and science. Through his leadership, vision, and dedication, Dr. Tian exemplifies the transformative power of scientific discovery.

📖Publications:

Paper Title: Development of bioassay platforms for biopharmaceuticals using Jurkat-CAR cells by AICD

  • Authors: Chen, D.; Li, S.; Yang, Y.; Zhang, R.; Tian, W.
  • Journal: Journal of Pharmaceutical and Biomedical Analysis
  • Year: 2024

Paper Title: IMM2520, a novel anti-CD47/PD-L1 bispecific antibody for cancer immune therapy

  • Authors: Yang, C.; Li, S.; Chen, D.; Tu, X.; Tian, W.
  • Journal: Heliyon
  • Year: 2024

Paper Title: Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy

  • Authors: Zhang, B.; Shi, J.; Shi, X.; Xu, L.; Li, W.
  • Journal: Drug Resistance Updates
  • Year: 2024

Paper Title: Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions

  • Authors: Li, X.; Tian, W.; Jiang, Z.; Leng, X.; Yu, J.
  • Journal: Cancer Immunology, Immunotherapy
  • Year: 2024

Paper Title: DNp73 enhances tumor progression and immune evasion in multiple myeloma by targeting the MYC and MYCN pathways

  • Authors: Liu, L.; Gong, D.; Sun, H.; An, G.; Hao, M.
  • Journal: Frontiers in Immunology
  • Year: 2024

 

Sidan Tian | FRP in Health & Medicine | Best Researcher Award

Dr. Sidan Tian | FRP in Health & Medicine | Best Researcher Award

Profiles:

Current Position 🌟

Sidan Tian is a dedicated Lecturer at the School of Life Science and Technology, Huazhong University of Science and Technology (HUST), a position he has held since 2022. Based at the National Engineering Research Center for Nanomedicine, his academic and professional endeavors revolve around creating innovative solutions in biomedical polymer research.

Publication Achievements 📚

Dr. Tian has made remarkable contributions to the field of polymer chemistry and biomedical engineering, publishing over ten SCI papers as the first or corresponding author. His work includes three articles in the prestigious Nature Communications, alongside publications in highly reputed journals such as the Journal of the American Chemical Society (JACS), ACS Nano, and Nano Letters. These publications showcase the originality and impact of his research on degradable polymers and their biomedical applications.

Ongoing Research 🔬

Dr. Tian’s current research focuses on the design, synthesis, and application of degradable biomedical conjugated polymers. 

  1. Co-Crystal Template Assisted Topological Polymerization: Developing novel degradable polydiacetylene molecules using co-crystal templates.
  2. ROS-Controlled Degradation: Innovating a method to achieve oxidation degradation of polydiacetylenes, resulting in small molecule carboxylic acids and revealing significant biochemical mechanisms.
  3. Biomedical Applications: Exploring the physiological impacts of degradation processes and constructing advanced biomaterials using degradable polydiacetylenes.

Research Interests 🌍

  • Polymer Chemistry and Physics: With a focus on degradable materials.
  • Biomedical Materials Development: Including applications for diagnostics and therapeutics.
  • Mechanistic Studies: Understanding the degradation pathways of polydiacetylenes.

His work bridges the gap between material science and medicine, enhancing therapeutic solutions for global health challenges.

Academic Background 🎓

Dr. Tian’s academic journey began at the University of Science and Technology of China (USTC), where he earned a Bachelor of Science in Polymer Materials and Engineering in 2011. He then pursued a Ph.D. in Polymer Chemistry and Physics at USTC, graduating in 2017. This robust academic foundation has equipped him with the expertise needed to excel in the interdisciplinary realm of polymer chemistry and biomedical innovation.

Scholarships and Awards 🏅

  • Selection for the “3551 Outstanding Young Talent” Project.
  • Funding from competitive grants such as the National Natural Science Foundation of China (NSFC) Young Scientist Project, a Postdoctoral Special Fund, and a Postdoctoral Fund for General Programs.

These awards underscore his leadership and excellence in scientific research.

Professional Associations 🤝

Dr. Tian is actively involved in the academic community, participating in key professional organizations that foster innovation in polymer science and biomedical materials.

Training & Workshops 🎓

Throughout his career, Dr. Tian has attended numerous training programs and workshops that have enriched his expertise in polymer synthesis and biomedical applications. These experiences have bolstered his ability to address complex scientific challenges.

Oral Presentations 🎤

Dr. Tian has delivered impactful presentations at prominent scientific conferences, showcasing his cutting-edge research to international audiences. These opportunities have further cemented his reputation as a thought leader in his field.

Tasks Completed as a Researcher✅

  • Leading the synthesis and characterization of novel degradable polymers.
  • Developing innovative methods for polymer degradation.
  • Collaborating on major research and development programs, contributing significantly to groundbreaking findings.

Success Factors 💪

  • Innovative Thinking: Bringing fresh ideas to the field of polymer chemistry.
  • Interdisciplinary Approach: Bridging material science and biomedicine.
  • Commitment to Excellence: Consistently publishing high-impact research.

Laboratory Experience 📝

Dr. Tian’s laboratory work is characterized by meticulous experimentation and innovative techniques. His publications reflect a deep understanding of polymer chemistry and its applications, particularly in creating materials with enhanced degradability and biocompatibility.

📖Publications:

Paper Title: A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds

  • Authors: Cheng, L., Zhuang, Z., Yin, M., Tian, S., Luo, L.
  • Journal: Nature Communications
  • Year: 2024

Paper Title: Atomic-iodine-substituted polydiacetylene nanospheres with boosted intersystem crossing and nonradiative transition through complete radiative transition blockade for ultraeffective phototherapy

  • Authors: Zhao, D., Zhang, L., Yin, M., Meng, F., Luo, L.
  • Journal: Aggregate
  • Year: 2024

Paper Title: Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation

  • Authors: Li, W., Zhan, M., Wen, Y., Tian, D., Tian, S.
  • Journal: Pharmaceutics
  • Year: 2024

Paper Title: Microenvironment modulating nanogels by Shiitake-derived lentinan and a reactive oxygen species scavenging conjugated polymer for the treatment of Alzheimer’s disease

  • Authors: Xin, Y., Fang, F., Yue, Q., Luo, L., Meng, F.
  • Journal: Nano Today
  • Year: 2024

Paper Title: Carbon-Iodine Polydiacetylene Nanofibers for Image-Guided Radiotherapy and Tumor-Microenvironment-Enhanced Radiosensitization

  • Authors: Yin, M., Yuan, Y., Huang, Y., Tian, S., Liu, B.
  • Journal: ACS Nano
  • Year: 2024