Dr. Gilles Pagès | Health & Medicine | Research Excellence Award
Director of Research Exceptional Class | INSERM | France
Dr. Gilles Pagès is an internationally recognized scientist whose research has made substantial contributions to molecular and cellular biology, particularly in the fields of autophagy, intracellular signaling pathways, and mechanisms of disease progression. His work has played a pivotal role in understanding the regulation of mitogen-activated protein kinases (MAPKs), specifically p42MAPK and p44MAPK, which are fundamental to cell proliferation, differentiation, and survival processes. He has significantly advanced knowledge on the nuclear translocation of MAPKs in response to growth factors, thereby elucidating essential regulatory steps in fibroblast signaling. Additionally, his groundbreaking study demonstrating defective thymocyte maturation in ERK1 knockout models has deepened scientific understanding of immune system development, highlighting critical links between signal transduction and immune function. Dr. Pagès has also contributed to receptor biology, including research on thrombin receptor function related to calcium mobilization. He is recognized globally for co-authoring the comprehensive consensus resource “Guidelines for the use and interpretation of assays for monitoring autophagy,” which remains a cornerstone reference widely used to standardize experimental approaches and ensure accurate interpretation in autophagy research across disciplines. With publications in top-tier journals such as Science and PNAS and exceptional citation impact reflecting widespread influence, his work supports advancement in disease modeling, oncology, and therapeutic innovations. Dr. Pagès continues to drive scientific progress through rigorous experimental research, impactful knowledge dissemination, and leadership in collaborative initiatives that strengthen the global research community.
Featured Publications
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., … Pagès, G. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1–382.
Pagès, G., Lenormand, P., L’Allemain, G., Chambard, J. C., Meloche, S., & Pouysségur, J. (1993). Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proceedings of the National Academy of Sciences, 90(18), 8319–8323.
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., … Pouysségur, J. (1999). Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science, 286(5443), 1374–1377.
Lenormand, P., Sardet, C., Pagès, G., L’Allemain, G., Brunet, A., & Pouysségur, J. (1993). Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. The Journal of Cell Biology, 122(5), 1079–1088.
Rasmussen, U. B., Vouret-Craviari, V., Jallat, S., Schlesinger, Y., Pagès, G., … G. G. (1991). cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization. FEBS Letters, 288(1–2), 123–128.